• Gamma Aminobutyric Acid is the chief inhibitory neurotransmitter which plays a critical role in the sedative and depressive functions of the brain, and has been positively associated with the regulation of the sleep-wake cycle.
  • Users often report an increase in dreaming intensity and duration.
  • Supplementation has shown a 5.5 fold increase in plasma growth hormone levels 90 minutes after GABA administration.
  • Common dosing is 2,000-5,000mg, with users reporting mild side effects such as tingling/flushing on the head and extremities with higher doses.
  • MorphoREM contains a very efficacious but tolerable 3,000mg dose per serving.

Chinese Skullcap

  • Skullcap is rich in a compound called Baicalein, which is a potent GABAA receptor activator.
  • Elicits relaxing, sedative, hypnotic, and anti-anxiety effects.
  • Increases deep sleep as well as REM sleep.

Valerian Root

  • Valeriana officinalis, also known as valerian root, is an herbal tea and supplement ingredient commonly used for its sedative and anxiety-reducing effects.
  • Users often report having an easier, faster time falling asleep as well as an increase in sleep quality, primarily by enhanced GABA signaling.
  • Shown to have similar sleep enhancing effects as prescription drugs but with less side effects.
  • MorphoREM contains 500mg Valerian root extract per serving.


  • Withania somnifera, commonly known as Ashwagandha, is an herb that is known to be an adaptogen. It reduces cortisol (the stress hormone), increases testosterone levels and reduces stress-induced side effects.
  • Sensoril® is an Ashwagandha extract that is backed by several randomized, double-blind, placebo controlled human clinical trials and is more commonly known as a more relaxing and sedative form of Ashwagandha. 
  • Significantly reduces the immunosuppressive effect of stress.
  • Improves physical performance.
  • Reduces low-density Lipoprotein (LDL) cholesterol.
  • MorphoREM contains the research supported dose of 450mg Sensoril® Ashwagandha per serving.


  • 5-hydroxytryptophan increases brain serotonin levels, which is one of the principal neurotransmitters involved in happiness and anti-depression. Its actions are more 'euphoric' or happiness inducing rather than stimulatory. 5-HTP has also been shown to increase satiety after a meal.
  • A typical dose of 5-HTP is in the range of 300-500mg, taken either once daily or in divided doses. Taking too much 5-HTP or other serotonin boosting supplements can cause serotonin syndrome, or serotonin toxicity, so it is wise to supplement with the lower end of the efficacious dosing.
  • MorphoREM contains a potent but safe 300mg 5-HTP per serving.


  • The relaxing amino acid found in tea, theanine promotes relaxation without sedation; it helps you stay calm without making you tired or drowsy.
  • Reduces stress and improves attention.
  • Theanine helps take off the ‘edge’ of many stimulants, and a synergistic effect is seen when coupled with caffeine in promoting cognition and attention.
  • Theanine is commonly dosed between 100-200mg prior to activity and higher doses for relaxation and stress reduction.
  • MorphoREM contains 300mg L-Theanine per serving.


  • Melatonin is a hormone secreted in the brain that regulates sleep. The primary use of melatonin as a supplement is to normalize abnormal sleep patterns.
  • Other benefits of melatonin include general neuroprotective and beneficial eye health effects, as melatonin is a powerful antioxidant.
  • Melatonin is not associated with negative feedback (when taking supplementation causes your body to produce less of a hormone). It is also not addictive, and is not toxic.
  • For regulating the sleep cycle, doses between 500mcg (0.5mg) and 5mg seem to work.
  • MorphoREM contains 5mg Melatonin per serving.

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